An analytical basis for assaying buried biological contamination Interim report

Assay techniques for determining biological contamination of spacecraft material

Early pregnancy loss : pretreat with mifepristone?

Review of: Schreiber CA, Creinin MD, Atrio J, et al. Mifepristone pretreatment for the medical management of early pregnancy loss. N Engl J Med. 2018;378:2161-2170.Early pregnancy loss : pretreat with mifepristone? Yes. While medical management of early pregnancy loss with misoprostol frequently results in treatment failure, pretreating with mifepristone can increase efficacy. PRACTICE CHANGER: Pretreat patient with oral mifepristone prior to using vaginal misoprostol to increase the efficacy of medical management of early pregnancy loss over that with misoprostol alone. STRENGTH RECOMMENDATION: B: Based on a single, well-executed, randomized controlled trial.Keri Bergeson, MD; Randolph J. Kline, MD; Shailendra Prasad, MBBS, MPH; University of Washington, Department of Family Medicine, Seattle (Dr. Bergeson); Nellis AFB Family Medicine Residency, Las Vegas, NV (Dr. Kline); Department of Family Medicine and Community Health, University of Minnesota, Minneapolis (Dr. Prasad

Words Volume 1 2007-2009

https://openspace.dmacc.edu/words/1000/thumbnail.jp

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

The generation of antitumor CD8+ T cell responses requires type I interferon responsiveness in host antigen-presenting cell

Use of Motor Abundance in Young and Older Adults during Dual-Task Treadmill Walking

Contains fulltext : 110120.pdf (publisher's version ) (Open Access)Motor abundance allows individuals to perform any task reliably while being variable in movement's particulars. The study investigated age-related differences in this feature when young adults (YA) and older adults (OA) performed challenging tasks, namely treadmill walking alone and while performing a cognitive task. A goal function for treadmill walking was first defined, i.e., maintain constant speed at each step, which led to a goal equivalent manifold (GEM) containing all combinations of step time and step length that equally satisfied the function. Given the GEM, amounts of goal-equivalent and non-goal-equivalent variability were afterwards determined and used to define an index providing information about the set of effective motor solutions relative to the GEM. The set was limited in OA compared to YA in treadmill walking alone, indicating that OA made less flexible use of motor abundance than YA. However, this differentiation between YA and OA disappeared when concurrently performing the cognitive task. It is proposed that OA might have benefited from cognitive compensation

Speech Communication

Contains reports on five research projects.C.J. Lebel FellowshipNational Institutes of Health (Grant 5 T32 NSO7040)National Institutes of Health (Grant 5 R01 NS04332)National Institutes of Health (Grant 5 R01 NS21183)National Institutes of Health (Grant 5 P01 NS13126)National Institutes of Health (Grant 1 PO1-NS23734)National Science Foundation (Grant BNS 8418733)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0341)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0290)National Institutes of Health (Grant RO1-NS21183), subcontract with Boston UniversityNational Institutes of Health (Grant 1 PO1-NS23734), subcontract with the Massachusetts Eye and Ear Infirmar

Cardiac lymphatics in health and disease

The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and nutritional lipid uptake and transport, as well as in reverse cholesterol transport. In this Review, we discuss the physiological role of the lymphatic system in the heart in the maintenance of cardiac health and describe alterations in lymphatic structure and function that occur in cardiovascular pathology, including atherosclerosis and myocardial infarction. We also briefly discuss the role that immune cells might have in the regulation of lymphatic growth (lymphangiogenesis) and function. Finally, we provide examples of how the cardiac lymphatics can be targeted therapeutically to restore lymphatic drainage in the heart to limit myocardial oedema and chronic inflammation.Peer reviewe

Local Land Use Regulation for the Location and Operation of Tobacco Retailers

Abstract The best predictor of adolescent experimentation with cigarettes is the perception by youth that cigarettes are easily available. Not only does youth smoking have life-long and life-ending health implications, but it is also a leading indicator of other high-risk behaviors among youth. As a result, local communities have a vested interest in the availability and placement of tobacco products, particularly with respect to youth access and exposure to these products. One option to reduce youth access to tobacco may be to use local land use regulations, such as zoning laws, to control the location and operation of tobacco retailers. This law synopsis describes local authority for land use regulation, lists types of local land use regulation, presents examples in which California communities have employed land use regulation to control the placement of tobacco-only stores, and briefly reviews two important issues local governments should consider in this area of the law. Finally, the author highlights the manner in which land use regulation has been successfully applied to other areas of public health